![]() ![]() This review summarizes the recent new forms for building electrospun 3D nanofiber scaffolds for TE applications. The variation among scaffold structures, functions and applications depends on the selection of electrospinning materials and methods as well as on the post-processing of electrospun scaffolds. Moreover, the 3D morphology regulates cellular interaction and mediates growth, migration, and differentiation of cell for matrix remodeling. Unlike normal densely-packed two-dimensional (2D) nanofibrous membranes, 3D electrospun nanofiber scaffolds are dedicated to more precise spatial control, endowing the scaffolds with a sufficient porosity and 3D environment similar to the in vivo settings as well as optimizing the properties, including injectability, compressibility, and bioactivity. Ībstract = "Electrospinning is widely accepted as a technique for the fabrication of nanofibrous three-dimensional (3D) scaffolds which mimic extracellular matrix (ECM) microenvironment for tissue engineering (TE). Meanwhile, the current challenges and prospects of 3D electrospun scaffolds are rationally discussed, providing an insight into developing the vibrant fields of biomedicine. A variety of approaches aimed at the fabrication of 3D electrospun scaffolds, such as multilayering electrospinning, sacrificial agent electrospinning, wet electrospinning, ultrasound-enhanced electrospinning as well as post-processing techniques, including gas foaming, ultrasonication, short fiber assembly, 3D printing, electrospraying, and so on are discussed, along with their advantages, limitations and applications. doi: 10.1177/1528083707078133.Electrospinning is widely accepted as a technique for the fabrication of nanofibrous three-dimensional (3D) scaffolds which mimic extracellular matrix (ECM) microenvironment for tissue engineering (TE). Electrospun porous mats for high efficiency filtration. doi: 10.4028/ -ĭotti F., Varesano A., Montarsolo A., Aluigi A., Tonin C., Mazzuchetti G. Design and Manufacture of Nanofibers Using Electrospinning Technique for Aerospace Application. Nisha M., Singh D., Freesta Shiny J., Sasirekha B. Electrospinning-based (bio) sensors for food and agricultural applications: A review. Mercante L.A., Scagion V.P., Migliorini F.L., Mattoso L.H., Correa D.S. The history of the science and technology of electrospinning from 1600 to 1995. ![]() Tucker N., Stanger J.J., Staiger M.P., Razzaq H., Hofman K. Perspectives and challenges in tissue engineering and regenerative medicine. ![]()
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